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Evidence for a vasodepressor effect of the angiotensin-converting enzyme inhibitor, MK421 (enalapril), independent of blockade of angiotensin II formation.
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Patients were ineligible if they were over 80 years of age or had any of the following: hemodynamically serious valvular disease requiring surgery, unstable angina pectoris, angina thought to be severe enough to require revascularization procedures, myocardial infarction during the previous month, severe pulmonary disease, serum creatinine level higher than 177 μmol per liter (2 mg per deciliter), or any other disease that might substantially shorten survival or impede participation in a long-term trial.
Dallavolta S "Safety and efficacy study of delapril versus enalapril in patients with congestive heart failure.
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